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edit cytochrome P450, family 26, subfamily C, polypeptide 1 Identifiers Symbols CYP26C1; FLJ45301 External IDs OMIM: 608428 MGI: 2679699 HomoloGene: 28089 GeneCards: CYP26C1 Gene EC number 1.14.-.- Gene Ontology Molecular function • electron carrier activity • metal ion binding • heme binding • retinoic acid 4-hydroxylase activity • iron ion binding • monooxygenase activity • retinoic acid binding Cellular component • membrane • microsome • integral to membrane • endoplasmic reticulum membrane Biological process • anterior/posterior pattern formation • neural crest cell development • retinoic acid catabolic process • organelle fusion • negative regulation of retinoic acid receptor signaling pathway • central nervous system development • oxidation reduction Sources: Amigo / EGO Orthologs Species Human Mouse Entrez 340665 546726 Ensembl ENSG00000187553 ENSMUSG00000062432 UniProt Q6V0L0 B2RXA7 RefSeq (mRNA) NM_183374 NM_001105201 RefSeq (protein) NP_899230 NP_001098671 Location (UCSC) Chr 10: 94.81 - 94.82 Mb Chr 19: 37.76 - 37.77 Mb PubMed search [1] [2] CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.[1] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.[2] References ^ Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297.  ^ "Entrez Gene: CYP26C1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340665.  Further reading Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.  Rat E, Billaut-Laden I, Allorge D, et al. (2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida.". Birth Defects Res. Part a Clin. Mol. Teratol. 76 (6): 491–8. doi:10.1002/bdra.20275. PMID 16933217.  Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.  Wan C, Shi Y, Zhao X, et al. (2009). "Positive association between ALDH1A2 and schizophrenia in the Chinese population.". Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (8): 1491–5. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508.  Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMID 16385451.  This article incorporates text from the United States National Library of Medicine, which is in the public domain. This genetics article is a stub. You can help Wikipedia by expanding it. v • d • e v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14) CYP1 A1 · A2 · B1 CYP2 A6 · A7 · A13 · B6 · C8 · C9 · C18 · C19 · D6 · E1 · F1 · J2 · R1 · S1 · U1 · W1 CYP3 (CYP3A) A4 · A5 · A7 · A43 CYP4 A11 · A22 · B1 · F2 · F3 · F8 · F11 · F12 · F22 · V2 · X1 · Z1 CYP5-20 CYP5 (A1) · CYP7 (A1, B1) · CYP8 (A1, B1) · CYP11 (A1, B1, B2) · CYP17 (A1) · CYP19 (A1) · CYP20 (A1) CYP21-51 CYP21 (A2) · CYP24 (A1) · CYP26 (A1, B1, C1) · CYP27 (A1, B1, C1) · CYP39 (A1) · CYP46 (A1) · CYP51 (A1)