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(February 2009) edit Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin) Identifiers Symbols OVGP1; EGP; CHIT5; MUC9; OGP External IDs OMIM: 603578 MGI: 106661 HomoloGene: 74442 GeneCards: OVGP1 Gene Gene Ontology Molecular function • catalytic activity • chitinase activity • cation binding Cellular component • extracellular space Biological process • carbohydrate metabolic process • chitin catabolic process • single fertilization • female pregnancy Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5016 12659 Ensembl ENSG00000085465 ENSMUSG00000074340 UniProt Q12889 Q54AJ4 RefSeq (mRNA) NM_002557 NM_007696 RefSeq (protein) NP_002548 NP_031722 Location (UCSC) Chr 1: 111.76 - 111.77 Mb Chr 3: 106.1 - 106.12 Mb PubMed search [1] [2] Oviduct-specific glycoprotein is a protein that in humans is encoded by the OVGP1 gene.[1][2][3] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.[3] References ^ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.  ^ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.  ^ a b "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016.  Further reading Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct.". Endocrinology 122 (4): 1639–45. doi:10.1210/endo-122-4-1639. PMID 3278893.  Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins.". J. Dent. Res. 76 (3): 734–43. doi:10.1177/00220345970760030501. PMID 9109822.  Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.". J. Dent. Res. 79 (2): 732–9. doi:10.1177/00220345000790020601. PMID 10728974.  Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter.". Mol. Hum. Reprod. 8 (2): 167–75. doi:10.1093/molehr/8.2.167. PMID 11818519.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle.". J. Assist. Reprod. Genet. 19 (12): 569–76. doi:10.1023/A:1021263132176. PMID 12503889.  Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein.". Hereditas 139 (1): 75–9. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Woo MM, Alkushi A, Verhage HG, et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer.". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.  Ling L, Lee YL, Lee KF, et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line.". Fertil. Steril. 84 Suppl 2: 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.  Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9.". Mol. Hum. Reprod. 12 (4): 275–82. doi:10.1093/molehr/gal028. PMID 16567366.  Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it. v • d • e