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edit Ras homolog gene family, member T1 Identifiers Symbols RHOT1; ARHT1; FLJ11040; FLJ12633; MIRO-1 External IDs MGI: 1926078 HomoloGene: 56803 GeneCards: RHOT1 Gene Gene Ontology Molecular function • nucleotide binding • molecular_function • calcium ion binding • GTP binding • hydrolase activity Cellular component • intracellular • mitochondrion • membrane • integral to membrane • outer membrane • integral to mitochondrial outer membrane Biological process • apoptosis • small GTPase mediated signal transduction • cell homeostasis • mitochondrion transport along microtubule Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 55288 59040 Ensembl ENSG00000126858 ENSMUSG00000017686 UniProt Q8IXI2 Q8BG51 RefSeq (mRNA) NM_001033566 NM_021536 RefSeq (protein) NP_001028738 NP_067511 Location (UCSC) Chr 17: 27.49 - 27.58 Mb Chr 11: 80.03 - 80.08 Mb PubMed search [1] [2] Mitochondrial Rho GTPase 1 is an enzyme that in humans is encoded by the RHOT1 gene.[1][2] References ^ Fransson A, Ruusala A, Aspenstrom P (Feb 2003). "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis". J Biol Chem 278 (8): 6495–502. doi:10.1074/jbc.M208609200. PMID 12482879.  ^ "Entrez Gene: RHOT1 ras homolog gene family, member T1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55288.  Further reading Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Aspenström P, Fransson A, Saras J (2004). "Rho GTPases have diverse effects on the organization of the actin filament system.". Biochem. J. 377 (Pt 2): 327–37. doi:10.1042/BJ20031041. PMID 14521508.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.  This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it. v • d • e