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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions are available. (February 2009) edit Phosphodiesterase 1A, calmodulin-dependent Identifiers Symbols PDE1A; HCAM1; HSPDE1A; MGC26303 External IDs OMIM: 171890 MGI: 1201792 HomoloGene: 21043 GeneCards: PDE1A Gene Gene Ontology Molecular function • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • calmodulin binding • hydrolase activity Cellular component • cellular_component Biological process • signal transduction Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5136 18573 Ensembl ENSG00000115252 ENSMUSG00000059173 UniProt P54750 Q8BRR9 RefSeq (mRNA) NM_001003683 NM_001009978 RefSeq (protein) NP_001003683 NP_001009978 Location (UCSC) Chr 2: 182.72 - 183.1 Mb Chr 2: 79.64 - 79.93 Mb PubMed search [1] [2] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.[1][2][3] References ^ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.  ^ Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta 1517 (2): 278–87. PMID 11342109.  ^ "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5136.  Further reading Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  Snyder PB, Florio VA, Ferguson K, Loughney K (1999). "Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A).". Cell. Signal. 11 (7): 535–44. doi:10.1016/S0898-6568(99)00027-3. PMID 10405764.  Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.  Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.  Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.  Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants.". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.  Ritter M, Buechler C, Boettcher A, et al. (2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.". Genomics 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.  Lefièvre L, de Lamirande E, Gagnon C (2003). "Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa.". Biol. Reprod. 67 (2): 423–30. doi:10.1095/biolreprod67.2.423. PMID 12135876.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Goraya TA, Masada N, Ciruela A, Cooper DM (2004). "Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A.". J. Biol. Chem. 279 (39): 40494–504. doi:10.1074/jbc.M313441200. PMID 15272012.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Nagel DJ, Aizawa T, Jeon KI, et al. (2006). "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.". Circ. Res. 98 (6): 777–84. doi:10.1161/01.RES.0000215576.27615.fd. PMID 16514069.  This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it. v • d • e